One of the great things about Interactive Smart Vids is that it does not require complex video editing, since you have the option to use the "Headline and Choices" type of branch, where you'll have the option to create a headline (the question), along with up to 4 different choices for your viewer to choose from. You'll have the option to customize the button color, text color, and hover over color.
BUT, if your question and answers are already built into your video, you can use our "Clickable Areas" branch type, which are options that are not buttons, but instead are areas selected on top of your video that your viewer can click. The clickable area can be transparent, or you can set a background color.